Arlene Santana

A gas tanker explodes on a highway, resulting in multiple injuries; Jo and Meredith try to help a frantic woman, whose child has a mysterious illness; Alex is forced to work with Jo's boyfriend.

Issues surface when Derek's estranged sister, Amelia, visits unexpectedly; Meredith and Derek continue to try to ease Cristina back into surgery.

After a burn victim unexpectedly dies in the ER, the Chief and board member Jennings question the residents, as all the staff members defend their actions in an effort to save their jobs.

Through Lexie, Meredith tries to get Derek interested in a patient's rare brain tumor; Callie ends up being annoyed when Mark and Arizona finally form a friendship.

Derek and April fight to find a solution for the hospital; Cristina works to respect the wishes of a dying boy's family; Arizona identifies with a teenager who is facing similar problems.

Owen is faced with tough decisions as Seattle Grace spirals toward financial ruin; Jo and Alex try to save an infant's life; April turns to Jackson for dating advice.