Grissom and Sara close in on who framed Hodges; a cargo plane lands autonomously at McCarran Airport and everyone on board is dead.
Max puts CSI on lockdown when evidence in a new murder tips Grissom and Sara to a new suspect in the crime lab; Folsom and Allie investigate a series of chilling killings at a dilapidated clown-themed hotel.
An abandoned horse covered in blood leads the CSI team to a halfway house for convicted murderers; Grissom and Sara begin to circle their prime suspect in the David Hodges case.
An attack on Jim Brass kicks off a twisted conspiracy targeting the Las Vegas crime lab.
When David Hodges goes missing, the CSI team searches for any piece of evidence that can help locate him, clear his name and save the reputation of the crime lab.