Jessica Ann Collins

When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth (guest star Jessica Collins), who happens to be a doctor herself, specializing in her daughter’s condition. The team must also deal with the battles raging between Emily’s mother and father who have conflicting views on how to handle her health issues. When searching the family’s home for clues to Emily’s illness, the team realizes that Elizabeth‘s determination to cure her daughter could be the very thing that is killing her. Meanwhile, House and Wilson take a little vacation.

A teenage girl is sent to a psychiatric clinic when her family observes her very odd behaviour following the death of her twin sister. During a clinic group outing in town, the girl runs away and hides in Melinda's store, where her twin sister appears and blames Melinda for revealing the girl's whereabouts to clinic authorities.