Alex gains the trust of Annie, a nervous patient with an extraordinarily large tumor, only to humiliate himself in front of her later. Meanwhile Derek chooses Meredith to assist with an elderly Parkinson’s patient who may need surgery -- but Bailey disapproves of their relationship and is determined to make Meredith suffer -- and tensions escalate between Burke and Shepherd.
More is revealed about Olivia's estranged relationship with her father through flashbacks. Meanwhile, both the White House and Pope and Associates are still in the middle of cleaning up the very big and very public mess they created.
A midwestern mum hires Pope and Associates under mysterious conditions that lead to a very dangerous situation. Meanwhile, Fitz and Mellie admit their true feelings for each other.
Olivia must make a very important decision that will affect all of her relationships within the White House, and Harrison's allegiance to the Gladiators is put to the ultimate test.
Olivia and the team try to handle uncovering the truth behind Operation Remington. However, things are harder for them as they must also manage a potential crisis with the Josie Marcus campaign.