Frasier follows Roz to her family home in Wisconsin to pose as her boyfriend, and spare her from embarrassment. Meanwhile, Niles plots to get rid of Daphne's mother.
Izzie faces her past and finds comfort in George, while Alex becomes more attached to Jane Doe (Elizabeth Reaser), Meredith and Derek question their own status, and Cristina resolves to fight for her relationship with Burke -- despite her past with Colin Marlow (Roger Rees).
Ian proposes to Susan, the Scavo pizzeria prepares for its grand opening, and Mike visits a hypnotherapist in hopes of remembering Monique.
Frasier becomes jealous when Maris' murder trial makes Niles a celebrity, and Roz has trouble dealing with her insulting sister.
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