As a parasitic fungal outbreak begins to ravage the world, Joel Miller attempts to escape the escalating chaos with his daughter and brother; twenty years later, a now hardened Joel and his partner, Tess, fight to survive under a totalitarian regime.

An Indonesian scientist makes a devastating discovery in 2003; In 2023, now outside of the quarantine zone, Joel and Tess clash over Ellie's fate as they navigate a long-abandoned Boston.

After abandoning their truck in Kansas City, Mo., Joel and Ellie attempt to escape without drawing the attention of a vindictive rebel leader.

While attempting to evade the rebels, Joel and Ellie cross paths with the most wanted man in Kansas City; Kathleen continues her hunt.

After ignoring the advice of locals, Joel and Ellie descend deeper into dangerous territory in search of the Fireflies and Tommy.