Academy Award nominee and multi-hyphenate Queen Latifah stars as Robyn McCall, an enigmatic former CIA operative who uses her extensive skills to help those with nowhere else to turn. As McCall acclimates to civilian life, she is compelled to use her considerable resources to help Jewel (Lorna Courtney), a teenager accused of murder and on the run from the criminals who framed her for the crime.

A mother's son is kidnapped by a human trafficker and will be executed unless McCall steals confidential information from her FBI agent employer; McCall enlists Aunt Vi to help uncover a secret Delilah is keeping from them both.

McCall tries to help an escaped prisoner who is wrongly accused of murder; McCall worries when her daughter, Delilah, stops hanging out with a close friend; Dante's search for McCall takes an unexpected turn.

McCall investigates a community activist's staged suicide and uncovers a connection between his murder and his protests over local real estate development; Delilah's driving lessons lead McCall and Aunt Vi to teach her an even bigger lesson.

When McCall tries to locate a missing British mathematician, she finds herself embroiled in an international fight for a revolutionary financial technology.

McCall tries to help a despondent college student being threatened by someone working for a rising politician; McCall worries when Delilah starts hanging out with a young girl who served time in juvenile detention.