Candice Afia

Derek's mother makes a surprise visit and meets Meredith for the first time; Mark tries to hide his relationship with Lexie; Cristina and Owen try to go on their first date.

Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.

Bailey and Seattle Grace's new pediatric surgeon try to save the life of a longtime patient; the admission of a death row inmate angers Derek; Izzie tells Alex that she has been seeing Denny.

An ambulance crash endangers the lives of the paramedics involved; Bailey treats a patient who refuses her help; Ava returns for Alex and meets his other girlfriend.

Cristina and Burke's wedding day arrives - along with the interns' first exam results - and a successor to the Chief is named, as Callie and George make a big decision about their relationship.

Addison, Naomi and Sam rush Archer to Seattle Grace, where they reunite with old friends in hope of saving his life; Izzie devises a medical game to teach the interns; Owen runs into someone significant from his past.