Krista Kalmus

Robin rediscovers a group of single girls who like to party; Ted pitches Barney a design for his company's headquarters.

Charlie has difficulty dealing with dating a slightly older woman.

Sandy, Seth and Ryan travel to Florida to visit Seth's Nana, Sophie (recurring guest star LINDA LAVIN - "Alice"), who is living in Miami Beach. While playing shuffleboard at the coastal retirement community, Seth and Ryan meet Mary-Sue (JAIME KING - "Sin City"), who helps Seth get center stage on the Music Video Nation spring break television special, hosted by Swerve (BRET HARRISON), along with Pixie (KRISTA KALMUS), who is a star of "Sherman Oaks: The Real Valley." Meanwhile, on the West Coast, Carter (recurring guest star BILLY CAMPBELL) packs his bags and leaves Kirsten alone at the offices of Newport Living, and Trey (recurring guest star LOGAN MARSHALL-GREEN) misinterprets Marissa's friendship. Also, rapper T.I. (himself) performs his hit single "Bring Em Out".

When a man next to House on a flight from Singapore to the United States becomes violently ill, Cuddy suspects he has a contagious virus.