Mac Brandt

Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns.

"Grey's Anatomy's" three-episode story arc continues with a part two that will challenge the interns of Seattle Grace -- and "Grey's" fans as well -- like never before.

While undergoing aggressive cancer treatment, Izzie focuses on planning Meredith and Derek's wedding; Callie's father visits; Owen seeks help with his PTSD.

Derek and Meredith get ready for their wedding; college students injured in a car accident are admitted to the ER; Izzie starts experiencing familiar symptoms.

Nora prepares to prove herself to Gallo and considers confessing to Ian; Jimmy and Crank's actions have devastating consequences; Jess considers taking matters into her own hands.

Time is running out, and Michael must enlist the help of his cellmate Sucre to help execute his elaborate escape plan. But Sucre wants no part of it and asks for a cell transfer, and Michael's new cellmate Haywire is even worse than he sounds. Meanwhile, Veronica meets a woman who may be able to help stop Lincoln's execution.