Mark Acheson

After Lex is accused of killing a young woman, Clark sets out to prove his innocence and asks an unlikely source for help--Lionel. Swearing he is a changed man, Lionel offers Clark insight into the crime, but he asks for something in return. Meanwhile, Lana meets Jason's parents and has a vivid flashback of the incident in Paris when she got her tattoo. Lana suspects that Jason's mother, Genevieve (recurring guest star JANE SEYMOUR - "Dr. Quinn, Medicine Woman," "Somewhere in Time"), was present when Lana got tattooed.

After Lana reads from a book written in the 1600s containing magical spells, she, Lois (recurring guest star ERICA DURANCE) and Chloe become possessed by witches who had been burned at the stake. The three witches have returned to seek revenge, and they search for the powerful Kryptonian crystals, wreaking havoc on the town. Clark attempts to stop the witches, but they strip him of his powers and force him to reveal the location of the crystal he hid in the cave.

Sam and Dean tackle a case where people vanish into thin air, leaving only their clothes behind; Dean becomes a victim.

The agents investigate deaths and disappearances near a lake where small-town residents revive stories about a legendary killer sea-serpent.