Maisy Gibbons' secret hobby is exposed when she's arrested for prostitution, in full view of the residents of Wisteria Lane, and when news of a little black book surfaces, Bree becomes determined to suppress news of Rex's dalliance with the domestic dominatrix.
While a severely burnt teenager's blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines, determined to prove a former medical school colleague wrong.
Not sure whether to end his relationship with his current girlfriend Claire after having romantic dreams about Lana, Frasier is plagued by the unwanted advice of his exes, Lilith and Diane.
Frasier and Niles' spontaneous gesture to share a table with two strangers (Lisa Darr, Megan Mullally) leads to a double date followed by a weekend getaway at a mountain cabin.
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