Loreni Delgado

The team reopen a serial killer's case when a suspected murderer wakes up from a coma: he may have been involved in crimes committed in Roanoke, Virginia.

When a police officer with a gunshot wound to the head and uncontrollable laughter is admitted, House and the team are baffled. When Foreman begins showing the same symptoms, they race to determine the cause of the illness before Foreman's condition takes the same path.

Jack and the castaways begin their efforts to make contact with Naomi's rescue ship.

Jack is on his way to the radio tower with some of the survivors to contact Naomi's salvage ship, but Ben warns them that it could kill everyone on the island. He threatens to execute Sayid, Jin and Bernhard.