When a NYPD officer is hit by a car in the line of duty, the hospital is turned upside down trying to save her. Meanwhile, Kapoor and Iggy work with a patient struggling with a previous surgery.
The team searches for Gravitonium in a desperate bid to save the world; Hale and Ruby recruit another team member; Deke learns the truth about his grandparents.
As more Life Model Decoys manage to infiltrate S.H.I.E.L.D., suspicion begins to turn to paranoia among the members of Coulson's team.
With Nathaniel and Sibyl edging ever closer to eliminating S.H.I.E.L.D. from the history books, the agents must rely on their strengths to outsmart and outlast the Chronicoms.
Despite being scattered all across the galaxy, the team struggle to work to find its footing after losing Coulson.