Molly Kidder

The Chief's wife, Adele, rushes their niece to Seattle Grace, the hospital where she once had her prom, Izzie reveals her feelings for George to a mutual friend, and the reaction is not what she expects, Derek teaches Cristina how to be a better teaching resident.

The Seattle Grace staff continue to mourn George's death; George's mother arrives but is unsure of what to do with his organs.

Izzie returns to work while the Seattle Grace residents fear possible layoffs; Bailey and Alex's difficult case is further complicated by her schizophrenic son.

Derek faces a lawsuit on his first day as interim chief when a patient awakens from anesthesia during surgery; Mark refuses to speak to Lexie.

Meredith, Cristina, Izzie and Alex spend their first day as residents with their own interns, including George, repeating his internship after failing his exams, and Meredith's half-sister. Cristina searches for Burke, who is nowhere to be found and Richard resumes his position as chief of surgery.

Derek prepares to perform his first surgery since his breakdown; Owen has a PTSD episode which injures Cristina and puts their relationship in jeopardy.