Tim Hopper

Izzie faces her past and finds comfort in George, while Alex becomes more attached to Jane Doe (Elizabeth Reaser), Meredith and Derek question their own status, and Cristina resolves to fight for her relationship with Burke -- despite her past with Colin Marlow (Roger Rees).

After an expensive portrait is stolen from a young woman, Neal tries to uncover the secret behind its origin, and he works with Peter to set up a sting, hoping to catch the cunning and deadly culprit.

Severide is on edge after the arson attack, fearing what might be in store next. Shay and Dawson, meanwhile, plan to party away their problems.

Firehouse 51 must band together after a devastating fire catches them off guard. Vasquez continues his quest for answers.

Hakeem throws an epic 21st birthday party and live-streams it all on Empire Xstream. Meanwhile, suspicions surrounding Anika’s motives put the Lyons on high alert and the arrival of Giuliana gives Cookie a run for her money.

Gallo clashes with the new lieutenant temporarily filling in for Casey; Severide closes in on a dangerous and deadly arsonist.