Tim Hopper

Izzie faces her past and finds comfort in George, while Alex becomes more attached to Jane Doe (Elizabeth Reaser), Meredith and Derek question their own status, and Cristina resolves to fight for her relationship with Burke -- despite her past with Colin Marlow (Roger Rees).

Philip and Elizabeth are ordered to go through with a meeting that could potentially be a set-up. Stan's investigation puts him and the FBI even closer to Philip and Elizabeth.

Firehouse 51 must band together after a devastating fire catches them off guard. Vasquez continues his quest for answers.

Phillip is reunited with an old flame and the reunion leaves him questioning the nature of his relationship with Elizabeth. Meanwhile, Stan and Nina finally give in to temptation.

Elizabeth and Philip take increasingly greater risks and Stan's pursuit of Directorate S suddenly begins to yield unexpected results.

Severide is on edge after the arson attack, fearing what might be in store next. Shay and Dawson, meanwhile, plan to party away their problems.