Yvette Cruise

When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems. Meanwhile, as Dr. Webber recovers from brain surgery, it seems that his wife (guest starring Loretta Devine as Mrs. Webber) has some concerns about the state of their marriage.

As Meredith nervously awaits a final decision from Derek, her angst is interrupted when a train crash brings several seriously injured patients to the hospital, including Bonnie and Tom, a pair of passengers who've been impaled on a metal pole. And Addison Shepherd sees great potential in Izzie, who must decide whether her loyalty as Meredith's friend outweighs professional gain.

Gideon, Hotchner and their team head to Mexico to aid in the investigation of a serial killer who preys on the elderly.

One person's fight to live affects everyone at Seattle Grace, in the dramatic conclusion to "Grey’s Anatomy's" three-episode story arc.

Cristina scrubs in on the rare "humpty dumpty" procedure, much to the envy of her fellow doctors, Alex questions his future medical specialty, George and Addison work with a pregnant woman with an unusual dilemma, and Derek receives a surprise visit from his sister.

Earl faces a battle with government bureaucracy when he tries to make up for not paying taxes, and his efforts to atone leave him on the wrong side of the law. Meanwhile, Randy buys a moped.