Michael Scofield is a desperate man in a desperate situation. His brother, Lincoln Burrows, was convicted of a crime he didn't commit and put on Death Row. Michael holds up a bank to get himself incarcerated alongside his brother in Fox River State Penitentiary, then sets in motion a series of elaborate plans to break Lincoln out and prove his innocence. Once out of jail, their perils aren't over - the brothers must flee to escape recapture and battle an intricate political conspiracy that puts everyone's life at risk.