Don and Mimi Galvin's dream of raising a picture-perfect family in Colorado Springs is thwarted as their eldest son, Donald, begins to act strangely. What starts as sibling rivalry and bullying develops into a series of bizarre, unexplainable rituals.

When Donald is released from the hospital, the family’s home-life is thrown into turmoil, forcing some to leave. Brian's rockstar dreams end in tragedy.

After one family member dies, 14-year-old Peter has a psychotic breakdown and a family secret forces Mary into an unthinkable situation.

When matriarch Mimi dies, it causes a major rift in the family -- the next generation fears that they might develop schizophrenia too. Scientists and researchers use the Galvins' DNA to try and find a cure for the disease.