Life is sweet - or at least suite - for identical teenage twins Zack and Cody Martin after their mom, Carey, lands a job headlining at the five-star Tipton Hotel in Boston, which comes with an upper-floor suite. From that new roost, the twins turn the hotel into their playground, although the pranks are usually instigated by girl-obsessed Zack, not the more mature and intellectual Cody. The boys are sometimes `handled' by Maddie Fitzpatrick, the teenage candy-counter girl who also is the somewhat unlikely best friend of spoiled London Tipton, the daughter of the hotel's owner.