The Dracula clan played a central role in vampire myths through the 16th century, when the Corvin clan began to rule. Three children were born in 1999 that the prophecy says will rescue the Dracula clan.

A girl is kept under constant surveillance because her mothers are afraid she might injure herself. Japanese exchange student K and her Romanian friend Noa visit a castle in Transylvania, where they become vampires in rival clans.

The neo-vampires that run the Requiem hotel throw a dating party for singles. During the party, Manami is stabbed through the heart.

The Corvins lure young mortals to the Requiem and force them to live like animals. The mortals rebel to no avail. K reunites with Noa and they secretly take Manami to the Dracula clan, where she finds out her destiny.

The Draculas head to the surface to defeat the Corvins, while Manami and K return to the Tokyo Vampire Hotel. Noa confesses her love.

Yamada orders the humans to form couples within a given time frame and make love -- or else face death. Manami is captured and the Corvins suck her blood, awakening her special power.