Billy Green (Adam Pally), ten years past his prime, heads back to his hometown for Thanksgiving, desperate to relive past glories and reconnect with his old high school girlfriend, Kara (Rachel Bloom). But Kara is now dating Lowell (Vincent Kartheiser), the creepy loner from high school who has grown up to be the town's beloved pharmacist. When Billy begins to suspect Lowell is harboring a deadly secret, he becomes obsessed with proving Lowell is a murderer…or is Billy just a jealous idiot who can't let go of the past?