On the run from a bank robbery that left several police officers dead, Seth Gecko (George Clooney) and his paranoid, loose-cannon brother, Richard (Quentin Tarantino), hightail it to the Mexican border. Kidnapping preacher Jacob Fuller (Harvey Keitel) and his kids, the criminals sneak across the border in the family's RV and hole up in a topless bar. Unfortunately, the bar also happens to be home base for a gang of vampires, and the brothers and their hostages have to fight their way out.