Settling in for some time off in his suburban home, Ray Peterson's (Tom Hanks) vacation becomes a horror when the Klopeks, a suspiciously odd family, move in down the block. Enlisting the aid of his paranoid buddy, Art (Rick Ducommun), and his militia-man neighbor, Rumsfield (Bruce Dern), Ray sends his son and wife (Carrie Fisher) away on a trip while he investigates the Klopeks. When a neighbor disappears, Ray and his cohorts risk their lives to save their cul-de-sac from the clutches of evil.