Franck (Guillaume Canet), a boisterous restaurant chef, shares a large Paris apartment with Philibert (Laurent Stocker), a postcard salesman who prefers to keep the world at arm's length. Then one day, their neighbor, Camille (Audrey Tautou), becomes seriously ill, so Philibert invites her to stay with them. She initially clashes with the temperamental Franck, who is juggling work and taking care of his grandmother (Françoise Bertin). But soon the four are living together happily -- almost.