Eleanor commits to Franklin's uncertain political future; Betty unexpectedly becomes second lady upon Jerry's nomination; Michelle wrestles with the consequences of Barack becoming the first Black president of the United States.

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Franklin's marital indiscretions push Eleanor to socialize with more politically active women; a stubborn shoulder injury begins Betty's troubled history with pain medication; Michelle vows to put Chicago's inadequate health care system to task.

Eleanor holds the White House's first all-female press conference and grows closer to journalist Lorena "Hick" Hickock; Betty publicly announces her breast cancer diagnosis; Michelle prompts new legislation with her healthy school lunch program.

Eleanor doubles down on her efforts to confront racism; Betty helps Jerry secure the Republican nomination for reelection while her problems with addiction worsen; Michelle grieves after gun violence tragedies and advocates for legislative action.