Eleanor commits to Franklin's uncertain political future; Betty unexpectedly becomes second lady upon Jerry's nomination; Michelle wrestles with the consequences of Barack becoming the first Black president of the United States.

Eleanor, Betty and Michelle face challenges in their first days in office.

Young Eleanor makes her societal debut in New York and meets her ambitious cousin, Franklin; young Betty, trapped in an abusive marriage, finds herself pursued by hotshot lawyer Jerry; young Michelle trains an idealistic summer intern named Barack.

Franklin's marital indiscretions push Eleanor to socialize with more politically active women; a stubborn shoulder injury begins Betty's troubled history with pain medication; Michelle vows to put Chicago's inadequate health care system to task.

Eleanor holds the White House's first all-female press conference and grows closer to journalist Lorena "Hick" Hickock; Betty publicly announces her breast cancer diagnosis; Michelle prompts new legislation with her healthy school lunch program.

Eleanor moves Hick into the White House while Franklin has the FBI spy on her; Betty works to ratify the Equal Rights Amendment, which aggravates Jerry's staff; Michelle pushes Barack to support marriage equality despite his reelection concerns.