When Leonard and Sheldon meet Penny, Leonard is immediately interested in her, but Sheldon feels his friend is chasing a dream he'll never catch.

After Leonard tries to do a favor for Penny, Sheldon ruins the plan. Leonard volunteers to sign for a package, hoping to make a good impression on Penny.

When Leonard sees Penny kissing a guy in front of her apartment door he is devastated. The guys convince him to ask someone out at work, but when he tries and is brutally turned down by a geeky girl, he is even more depressed.

After being fired from his job, Sheldon attempts to explore the "dreadful" life beyond physics. But his initial thrill of shopping with Penny devolves over time to him weaving ponchos as a shut-in, forcing Leonard to call on Sheldon's mother, Mary (Laurie Metcalf - Roseanne ).

After sensing that his pursuit of Penny isn't going anywhere, Leonard agrees to an unexpected sexual encounter with fellow scientist Leslie Winkle (recurring guest star Sara Gilbert). The one-night stand throws Leonard and Sheldon deep into uncharted social waters.

Leonard, Sheldon, Wolowitz y Koothrappali asisten a la fiesta de Halloween de Penny.