Addison doubts her abilities as a doctor, Cristina pushes Burke's rehabilitation, one of the interns suffers their own medical emergency, and Izzie receives the surprise of her life.
Michael, Lincoln and Sara attempt to make contact with somebody who can be trusted with the recording, Mahone gives Bellick another job to do, and C-Note is faced with a terrible choice.
Michael walks into a trap in his attempts to put T-Bag back in jail, Sara awaits her fate in court, and Kellerman decides to take drastic action.
While the team investigate a series of random murders in northern Virginia, an unexpected arrival may hold a secret from Rossi's past.
Sam tries to take care of his sister, Corinne, but her mental condition makes that nearly impossible.