Medverkande
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Robert Downey Jr.Sherlock Holmes - Jude LawDr. John Watson
- Noomi RapaceMadam Simza Heron
- Jared Francis HarrisProfessor James Moriarty
- Rachel McAdamsIrene Adler
- Stephen FryMycroft Holmes
- Eddie MarsanInspector Lestrade
- Kelly ReillyMary Watson
- Jack LaskeyCarruthers
- Geraldine JamesMrs. Hudson
- William HoustonConstable Clark
- Paul AndersonColonel Sebastian Moran
- Wolf KahlerDoctor Hoffmanstahl
- Iain MitchellAuctioneer
- Guy RitchieRegissör
- Joel SilverProducent
- Lionel WigramProducent
- Susan DowneyProducent
- Dan LinProducent
- Bruce BermanProducent
- Steve Clark-HallProducent
- Michele MulroneyFörfattare
- Kieran MulroneyFörfattare
- Tony PeckhamFörfattare