House (Hugh Laurie) försöker lösa ett medicinskt mysterium bakom galler i säsongspremiären. Odette Annable ("Breaking In") går med i seriens rollbesättning. Jaleel White ("Räkna med bråk") och Michael Paré ("Eddie and the Cruisers") gästspelar.
New junior law-partner Pam learns her boss is involved in a mob bribery scheme.
The aliens who gave Ralph the suit ask him to stop a computerized missile launch which could start World War III.
Bill sends in baseball-fan Ralph to infiltrate a playoff-bound team whose members are being felled.
Ralph, Bill and Pam fend off the CIA, IRS, Treasury Department and police when Tony is suspected of arson.
