The war between humans and vampires continues, but the humans' best hope, human-vampire hybrid warrior Blade (Wesley Snipes), has been framed for countless murders, turning popular sentiment against him. The vampire leader responsible for Blade's bad publicity is Danica Talos (Parker Posey), who's determined to finally lead her bloodthirsty compatriots to victory. Now Blade must team up with a band of rogue vampire hunters (Ryan Reynolds, Jessica Biel) to save humanity.