Former models Derek Zoolander (Ben Stiller) and Hansel find themselves thrust back into the spotlight after living in seclusion for years. Invited to a major fashion event in Rome, the estranged friends are surprised to see how much the business has changed. Even more shocking is their encounter with Valentina Valencia, a special agent who needs their help. Someone is killing famous pop stars, and it's up to Derek and Hansel to help save the world's most beautiful people from a similar fate.