Gonzales and Coulson fight to put aside their differences as they work with an untrustworthy ally to attack Hydra.
As tensions rise between S.H.I.E.L.D. and the Inhumans, Skye finds her torn between the groups; Coulson reveals a secret.
S.H.I.E.L.D. puts it all on a line to survive a fight that blurs the line between friend and enemy; the team must make sacrifices that will alter relationships forever.
A shocking revelation and an impending decision about what to do with one of their own leaves the team broken; Ward and Agent 33 go on a personal mission.