Castle and Beckett discover an ER doctor who was gunned down in the street was a mob doctor to a mafia family with ties to Castle; Esposito and Lanie reach an important moment in their relationship.
After Air Force One is shot down in the desert, Jack's only hope of keeping the "nuclear football" out of the hands of the terrorists comes from two campers who saw the plane go down.
Scully pursues a photographer who can seemingly predict the deaths of other people.