Dr. Pol and his team handle animal emergencies in Central Michigan.

Dr. Pol, assisted by his son Charles, is faced with several difficult cases, including a police dog who is lethargic and losing weight for no obvious reason and an aggressive terrier whose leg seems broken yet is normal according to his x-ray. If that weren't enough, Dr. Pol must also attend to several emergency farm calls including treating a cow with a twisted stomach and one down on the ground with a prolapsed uterus. This caseload could be a struggle for vets half his age, but Dr. Pol takes it all in stride. Meanwhile, Charles, who's visiting from LA, gains a renewed respect for his dad as he watches him navigate the emotional and physical demands of working as a farm vet.

An Australian Sheepdog is brought to the clinic after eating a dead deer carcass which is poisonous to dogs. Then, Dr. Pol and son his Charles must wrestle a flock of sheep in order to take blood samples to test for OPP - Ovine Progressive Pneumonia, a progressive disease that is incurable and highly contagious. Back at the clinic, Dr. Brenda tests a lump in a Doberman's mammary gland and concludes it is pre-cancerous. Will she be able to successfully remove it to save the dog's life?

A Boer goat has lost 50 pounds after refusing to eat and Dr. Pol suspects a parasite is to blame. A French bulldog is brought into the clinic after being hit by a car. Dr. Pol must keep the dog overnight to x-ray him and to surgically remove his injured eye. And, Dr. Pol is praised by a local family for treating their English Springer Spaniel who has mange, a contagious skin diseases caused by parasitic mites.

A charity event causes Charles to dive into icy water.

Charles and Brenda are in charge of the clinic while Dr. Pol and his wife are on vacation.