In the series premiere, Harley Quinn is fed up being the Joker's sidekick and strikes out on her own - determined to become the criminal Queenpin of Gotham City.

Determined to become one of the vaunted Legion of Doom, Harley attempts to make a big splash by crashing one of their criminal enterprises with the help of her BFF, Poison Ivy.

Realizing that she needs a crew to pull off legit heists, Harley attempts to recruit disgraced Wonder Woman villain, Dr. Psycho and Clayface, Gotham's shapeshifting thespian extraordinaire.

Now that she's got a crew, up-and-coming supervillain Harley Quinn needs a nemesis. She ends up with an adolescent Robin, making her the laughing stock of the criminal underworld.

While trying to find a lair to house her crew, Harley suffers a paralyzing identity crisis. With the aid of Dr. Psycho's telepathic powers, the crew must enter Harley's mind to free her.

During a heist gone wrong, Clayface loses an arm - which turns out to be evidence to enterprising GCPD Commissioner Jim Gordon, but also a key witness against Harley and her crew.