This is a remake of the live-action Season 1 episode #6 "SKIN". During the search for their father, Sam and Dean investigate a small town where a series of strange murders have occurred. They soon discover the murders have been committed by a Shapeshifter, a monster who sheds his skin and can appear as anyone. Sam and Dean separately go to search the town but when Dean meets back up with Sam he becomes suspicious of his "brother’s" true identity too -- Why isn’t Sam mad that he called him "Sammy" ? Turns out the Shapeshifter has taken over Sam!!

This is a remake of the live-action Season 2 episode #16 "ROAD KILL". Sam and Dean investigate a series of strange accidents on a mountain road. They come across Molly who insists she and her husband just crashed their car, problem is her husband and the car are missing!! Dean and Sam keep Molly close as they find and burn the bones of the suspected ghost causing the accidents. But not everything is as it seems... including Molly.

This is a remake of the live-action Season 1 episode #9 "HOME". Following what Sam has seen as a vision, Sam and Dean visit their childhood home in Lawrence Kansas. Sam and Dean discover an unseen force is terrorizing the current residents of their house, a mother and her two children. Convinced that something evil is in their old house, Sam insists on staking it out to make sure the family stays safe. It doesn’t take long for things to turn deadly. An unexpected entity saves the boys and family... a spirit very close the Sam and Dean.

This is an anime-original episode. While driving through New Orleans, the Winchester boys are stopped by the police and arrested. It seems there have been a series of accidents caused by an Impala -- and the police think they’re the perps! Sam and Dean must hunt for the last vestiges of the ghost to salt and burn. It’s just too bad an Impala had to go too!

This is an anime-original episode. In a small town in Colorado, Sam and Dean investigate a series of cattle mutilations, the beasts have been drained of their blood. They run across Jason, a hunter who specializes in vampires, but wonder why he’s in town. Dean takes a shine to a whimpy kid, Ryan. But the kid and his father are hiding something. It’s revealed Jason is in town to kill them. They’re both vampires who have sworn off killing humans. Can Sam and Dean save two monsters that they are trained to hunt and gank?!

This is an anime-original episode. Going back in time we revisit the first time Sam meets Jessica, and learn the secret she shared with her childhood friends. Now that secret is coming back to kill them. Can Sam save the girls by himself? Drawn to stories of the strange deaths at Stanford, John and Dean are right around the corner -- literally. We finally get a glimpse into the lives of Jessica and Sam. But three years later, Sam is still standing in front of Jessica’s grave.