Nathan James returns home to Norfolk on a mission to produce and distribute the cure; Chandler sends his crew in search of their own friends and loved ones.
A small team heads to the jungles of Nicaragua to find monkeys for Rachel's vaccine trials; Chandler and his men face a moral dilemma when they encounter a former drug kingpin.
The crew of the Nathan James makes a discovery; Chandler sees an opportunity to add another ship to the fleet; Rachel is eager to find a lab that is better equipped to replicate the vaccine; Chandler and his team encounter an unexpected enemy.
Rachel works on a more efficient version of the cure; Alisha decodes a message found on a cell phone; a suspicious death forces Chandler to launch a murder investigation; the Nathan James heads to New Orleans.
The Coterie group goes out for an epic competitive bar crawl on Davia's birthday, causing tensions to run high between the romantic "rectangle" of Callie, Jamie, Gael and Bryan; Alice struggles with Sumi's constant flirtations.