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Alex gains the trust of Annie, a nervous patient with an extraordinarily large tumor, only to humiliate himself in front of her later. Meanwhile Derek chooses Meredith to assist with an elderly Parkinson's patient who may need surgery -- but Bailey disapproves of their relationship and is determined to make Meredith suffer -- and tensions escalate between Burke and Shepherd.

Olivia faces a decision that will affect her White House relationships; Harrison's loyalty is tested; Cyrus and Mellie scheme against Josie Marcus while the team works with her.

Olivia and the team must manage a potential crisis with the Josie Marcus campaign while investigating Operation Remington; Cyrus tries to take down Sally.

As they get closer to uncovering the mole's identity, Olivia and her team find themselves in an increasingly dangerous situation; the latest White House scandal pushes Cyrus over the edge.

In hope of recovering from public backlash, Mellie does a hard-hitting news interview; as Huck pushes Quinn away, her bloodlust threatens to put her in danger.