Pat Kramer (Lily Tomlin) leads the typical "American Dream" lifestyle, with husband Vance (Charles Grodin) making the money while she raises their two kids in suburban California. But when the chronic consumer gets poisoned by the chemicals in her household products, she suddenly shrinks to a tiny size and becomes a media sensation. In addition to the problem of her odd condition, the miniature Pat must also contend with a conniving corporation who wants to exploit her situation for evil.