Widowed cop Frank Conner (Andy Garcia) is determined to secure a bone marrow transplant for his son, Matt (Joseph Cross), who will die of leukemia if a suitable donor isn't found. Conner discovers that incarcerated serial murderer Peter McCabe (Michael Keaton) is a match for Matt, and the psychopath eventually agrees to donate marrow, but he escapes from the operating room just before the procedure. Conner quickly follows, but the scheming McCabe won't be easily apprehended.