When their parents decide to sell their home, siblings Maura (Amy Poehler) and Kate (Tina Fey) learn that they have one weekend to clean out the junk from their old bedroom. Unhappy with the news, the recently divorced Maura and her hotheaded sister make plans to throw one final bash to recapture their glory days with their former classmates. As the raging party begins to spiral out of control, the gals soon realize that there may not be a house left once the dust settles.