Detective Rita Rizzoli (Whoopi Goldberg) is accustomed to donning costumes and going undercover to nail crooks. But she'll be required to use all of her get-ups and more when a major cocaine ring is suspected of turning out a potent new strain of the drug, called "Fatal Beauty." With the help of her partner, Jimenez (Ruben Blades), and a former bodyguard for a local cartel (Sam Elliott), Rita will do whatever it takes to find out who's dealing Fatal Beauty and stop them.