Drug-addled, down-and-out musicians Cheech (Cheech Marin) and Chong (Tommy Chong) finally get a lucky break when two wealthy Arabs, Mr. Slyman (also Marin) and Prince Habib (also Chong), hire them to drive a limousine from Chicago to Las Vegas. What the hapless duo doesn't know is that millions are stashed in the seats of the car. Soon the clueless Cheech and Chong are selling off parts of the limo for money and wind up in the desert with their angry foreign employers in hot pursuit.