Captured by the Umbrella Corp., Alice (Milla Jovovich) receives genetic alterations that leave her with superhuman abilities. Hiding out in the Nevada desert, she joins forces with former cohorts Carlos (Oded Fehr) and L.J. (Mike Epps) as well as new survivors Claire (Ali Larter), K-Mart (Spencer Locke) and Nurse Betty (Ashanti) to eradicate the virus that threatens to turn every human on Earth into a zombie.