The enigmatic Dr. Helen Magnus (Amanda Tapping) recruits an insightful forensic psychiatrist Will Zimmerman (Robin Dunne) to join her in the quest to track, study and protect the strange, and often terrifying creatures that secretly populate our world.

Ashley (Emilie Ullerup) is confronted by the sinister John Druitt (Christopher Heyerdahl) who possesses a powerful force and a baffling knowledge of her mother, Magnus (Amanda Tapping). Dr. Will Zimmerman (Robin Dunne) must decide if he will take a leap of faith and join Magnus in the seemingly inexplicable world of the Sanctuary.

Dr. Helen Magnus (Amanda Tapping), her daughter Ashley (Emilie Ullerup), and new to the Sanctuary, Dr. Will Zimmerman (Robin Dunne) release three women from a mysterious crypt in Scotland, bringing them back to the Sanctuary for refuge. Unbeknownst to the team, and the women themselves, they have extraordinary powers. And their disappearance does not go undetected by a powerful cabal, resolute on reclaiming what it determines is theirs.

An investigation into a string of bizarre robberies leads Magnus (Amanda Tapping) and Will (Robin Dunne) to a crime ring of thieves who seem to be able to slip between the cracks of the law…literally.

Returning with an abnormal captured in the Himalayas, Magnus (Amanda Tapping) and Will (Robin Dunne) are stranded from civilization and aid after their plane goes down in a desolate mountain range. While anxiously waiting for a rescue team, the surviving passengers begin to fall victim to vicious and deadly attacks throughout the night. It becomes chillingly apparent that surviving the cold is the least of their worries and no one, not even Magnus and Will, is above suspicion.

When a mating pair of cute, furry and seemingly harmless abnormals is brought in for scientific study, the Sanctuary team begins to exhibit some hidden animal attractions for one another.