第 1 季，第 1 集: When a series of "vampire" murders sweeps the city, Toronto Police detective Nick Knight is put on the case. However, unknown to everyone except medical examiner Natalie Lambert, Nick is also a vampire trying to regain his own mortality. When the next victim is a guard at the Natural History Museum, Nick and Detective Schanke discover that a Mayan ceremonial goblet was also taken, one which curator Alyce Hunter notes was used to drink the blood of sacrifice victims. Forced to retreat to his loft apartment during the day, Nick darkens the room and drinks animal blood from a goblet identical to the one stolen from the museum while anxiously waiting for Natalie to find a cure. When Alyce comes across a century-old photograph of an archaeologist who looks exactly like Nick, she discovers the cup was one of a pair that, together, are thought to cure vampirism. Though attracted by the museum curator, Nick is forced to resist his impulse to drink her blood and returns home shaken by how easily he could have killed Alyce. Told that he must stop drinking blood for a cure to work, Nick insists that it is too difficult to change, but Natalie threatens to stop her treatments if he doesn't cooperate. Meanwhile, when a homeless couple disappears from his neighborhood, Nick worries that they are the latest victims of the vampire killer. After telling Natalie about Lacroix, the vampire who brought him over to the netherworld centuries ago, Nick reveals that his master would do anything to keep him from recovering his mortality. Suspecting Lacroix of being behind the killings and the theft of the goblet, Nick learns of the murder of his homeless friend, Topper, but wonders what has become of his companion, Jeanie. Turning to Janette, another vampire from 13th Century France, Nick is told of Lacroix's whereabouts and plunges headlong toward a confrontation, unaware he is being followed by Alyce.