Cross "What's Up Doc" with "Bring Me the Head of Alfredo Garcia" and you get this dark screwball comedy of murder and lost luggage. Mafia hitman Tommy Spinelli (Joe Pesci) is flying to San Diego with a bag that holds eight severed heads, which he's bringing to his superiors to prove that some troublesome rival mobsters are permanently out of the picture. Medical student Charlie Pritchett (Andy Comeau) is headed to Mexico with his fiancée Laurie Bennett (Kristy Swanson) to meet her parents. Charlie's suitcase is identical to Tommy's, and it's not until Tommy arrives in San Diego that he discovers that there are no heads in his bag, while Charlie realizes his duffel most certainly does not contain his vacation wardrobe. Tommy finds Charlie's address in the bag and heads to the fraternity house he calls home, where he drafts Charlie's friends Ernie (David Spade) and Steve (Todd Louiso) into finding him some replacement heads post-haste. Meanwhile, Laurie's parents (Dyan Cannon and George Hamilton) are a bit miffed to discover that their future son-in-law is traveling with a bag full of rotting heads, while Laurie is ready to give Charlie his walking papers. "Eight Heads In a Duffel Bag" was the directorial debut of screenwriter Tom Schulman, who won an Academy Award for his script for the movie "Dead Poets Society."