In this animated sequel, that ol' pal of ours Charlie Barkin returns to create chaos in heaven and on earth. The trouble begins when Charlie gets bored with the peaceful bliss of life in doggy heaven and begins dreaming of returning to Earth. Even the arrival of his former best pal Itchy does little to cheer him up. Then the wicked Carface steals Gabriel's horn and in the struggle it falls into San Francisco. Charlie and Itchy jump at the chance to retrieve the holy horn.